• ORGANIC CHEMISTRY OF BIOLOGICAL SYSTEMS

    ROBERTO BERLINCK’S RESEARCH GROUP – INSTITUTO DE QUÍMICA DE SÃO CARLOS, USP

  • ORGANIC CHEMISTRY OF BIOLOGICAL SYSTEMS

    ROBERTO BERLINCK’S RESEARCH GROUP – INSTITUTO DE QUÍMICA DE SÃO CARLOS, USP

  • ORGANIC CHEMISTRY OF BIOLOGICAL SYSTEMS

    ROBERTO BERLINCK’S RESEARCH GROUP – INSTITUTO DE QUÍMICA DE SÃO CARLOS, USP

  • ORGANIC CHEMISTRY OF BIOLOGICAL SYSTEMS

    ROBERTO BERLINCK’S RESEARCH GROUP – INSTITUTO DE QUÍMICA DE SÃO CARLOS, USP

NEWS

Recent Articles

From Angewandte Chemie International Edition

Total Synthesis of C30 Botryococcene and epi‐Botryococcene by a Diastereoselective Ring Opening of Alkenylcyclopropanes

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Synthesis, Structural Reassignment, and Antibacterial Evaluation of 2,18‐Seco‐Lankacidinol B

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Editorial – Empowering Students to Innovate: Engagement in Organic Chemistry Teaching

I recently had the pleasure of competing for the Robert Foster Cherry Award for Great Teaching given biennially by Baylor University. In preparing for the competition, I spent considerable time reflecting on my own past experiences as a student, as well as the key philosophies that have helped to transform organic chemistry—often dreaded by students—into one of the most popular classes on the UCLA campus. In this Guest Editorial, I focus on just one key aspect, which involves capturing the extraordinary potential of our students to innovate.

As a “pre‐med” student at NYU, I took chemistry courses out of necessity. “OChem” in particular was reputed to be an intense weed‐out class that required exhaustive memorization and regurgitation of information. On our first day of class in 1997, Professor Yorke Rhodes convinced us otherwise. He told tales of the great contemporary organic chemists who were educated at NYU, such as Professors Eric Jacobsen and Al Myers, along with recent graduate Phil Baran, who was already a rising star in graduate school at the time.

(read more…)

Enantioselective Total Synthesis of (+)‐Plumisclerin A

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Total Synthesis of Epicolactone

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From Natural Product Reports

Hot off the Press

A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as huperphlegmine A from Huperzia phlegmaria.

Graphical abstract: Hot off the Press

From the Journal of Natural Products

Medermycin-Type Naphthoquinones from the Marine-Derived Streptomyces sp. XMA39

np-2018-00544u_0007

From ACS Medicinal Chemistry Letters

Marine Natural Products in Medicinal Chemistry

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Recent Articles

Toward Understanding the Chemistry and Biology of 1-Deoxy-d-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism

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Synthetic Lava Brings Eruption into the Lab

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Molecular Basis for Olefin Rearrangement in the Gephyronic Acid Polyketide Synthase

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Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway

cb-2018-00673z_0006

Unexpected Bacterial Origin of the Antibiotic Icosalide: Two-Tailed Depsipeptide Assembly in Multifarious Burkholderia Symbionts

cb-2018-006004_0005

Chemistry and Properties of Indolocarbazoles

cr-2018-001865_0130

Open Access With A Vengeance

Derek Lowe – Here’s something to keep an eye on: eleven of the largest national research funding agencies in Europe have announced a plan to require open-access publication of papers arising from their grants. The plan is that by 2020, all such work must be published in compliant open-access journals or on compliant open-access platforms. (read more…)

Sulfonic Acid-Containing Flavonoids from the Roots of Phyllanthus acidus

np-2018-003225_0004 (1)

Calothrixamides A and B from the Cultured Cyanobacterium Calothrix sp. UIC 10520

The first author of this paper is Camila M. Crnkovic, a Brazilian student who obtained a PhD degree at the School of Pharmacy, University of Illinois, Chicago, under the supervision of Jimmy Orjala.

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GEX1A, a Polyketide from Streptomyces chromofuscus, Corrects the Cellular Defects Associated with Niemann-Pick Type C1 in Human Fibroblasts

np-2018-00314x_0005

Peloruside E (22-Norpeloruside A), a Pelorusane Macrolide from the New Zealand Marine Sponge Mycale hentscheli, Retains Microtubule-Stabilizing Properties

np-2018-005577_0003

Colocynthenins A–D, Ring-A seco-Cucurbitane Triterpenoids from the Fruits of Citrullus colocynthis

np-2018-00461s_0004

Hexaricins, Pradimicin-like Polyketides from a Marine Sediment-Derived Streptosporangium sp. and Their Antioxidant Effects

np-2018-003972_0003

Investigation of the Biosynthesis of the Lasso Peptide Chaxapeptin Using an E. coli-Based Production System

np-2018-00392g_0004

Diaporindenes A–D: Four Unusual 2,3-Dihydro-1H-indene Analogues with Anti-inflammatory Activities from the Mangrove Endophytic Fungus Diaporthe sp. SYSU-HQ3

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Divergent Diels–Alder Reactions in the Biosynthesis and Synthesis of Endiandric-Type Tetracycles: A Computational Study

jo-2018-01594c_0006

Target Identification of Yaku’amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase

ja-2018-07339c_0009

C–H Hydroxylation in Paralytic Shellfish Toxin Biosynthesis

ja-2018-08901h_0007 (1)

Divergent Entry to Gelsedine-Type Alkaloids: Total Syntheses of (−)-Gelsedilam, (−)-Gelsenicine, (−)-Gelsedine, and (−)-Gelsemoxonine

ja-2018-081272_0006

Sodorifen Biosynthesis in the Rhizobacterium Serratia plymuthica Involves Methylation and Cyclization of MEP-Derived Farnesyl Pyrophosphate by a SAM-Dependent C-Methyltransferase

ja-2018-08510r_0008

Metabolic and Biosynthetic Diversity in Marine Myxobacteria

Substrate-assisted enzymatic formation of lysinoalanine in duramycin

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Biosynthesis and chemical diversity of β-lactone natural products

Graphical abstract: Biosynthesis and chemical diversity of β-lactone natural products

The architectures of iterative type I PKS and FAS

Graphical abstract: The architectures of iterative type I PKS and FAS

Pyridoxal phosphate-dependent reactions in the biosynthesis of natural products

Graphical abstract: Pyridoxal phosphate-dependent reactions in the biosynthesis of natural products

Unusual subunits are directly involved in binding substrates for natural rubber biosynthesis in multiple plant species

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Recent Articles

Reconstitution of Enzymatic Carbon–Sulfur Bond Formation Reveals Detoxification-Like Strategy in Fungal Toxin Biosynthesis

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Mycobacterial MenJ: An Oxidoreductase Involved in Menaquinone Biosynthesis

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Estudo traz novas pistas sobre sofisticada sociedade que ergueu enigmáticas estátuas gigantes da Ilha de Páscoa – A maior parte dos quase 900 moais mede de 4 a 6 metros de altura

Céticos do clima devem pedido de desculpas a quem acreditou neles

Abyssomicin Monomers and Dimers from the Marine-Derived Streptomyces koyangensis SCSIO 5802

np-2018-00448j_0008

Review of Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery

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Staurosporine Derivatives Generated by Pathway Engineering in a Heterologous Host and Their Cytotoxic Selectivity

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Complete Genome of Micromonospora sp. Strain B006 Reveals Biosynthetic Potential of a Lake Michigan Actinomycete

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Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium

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Ansamycins with Antiproliferative and Antineuroinflammatory Activity from Moss-Soil-Derived Streptomyces cacaoi subsp. asoensis H2S5

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