Recent Articles

Toward Understanding the Chemistry and Biology of 1-Deoxy-d-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism



Synthetic Lava Brings Eruption into the Lab


Molecular Basis for Olefin Rearrangement in the Gephyronic Acid Polyketide Synthase



Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway


Unexpected Bacterial Origin of the Antibiotic Icosalide: Two-Tailed Depsipeptide Assembly in Multifarious Burkholderia Symbionts


Chemistry and Properties of Indolocarbazoles


Open Access With A Vengeance

Derek Lowe – Here’s something to keep an eye on: eleven of the largest national research funding agencies in Europe have announced a plan to require open-access publication of papers arising from their grants. The plan is that by 2020, all such work must be published in compliant open-access journals or on compliant open-access platforms. (read more…)

Sulfonic Acid-Containing Flavonoids from the Roots of Phyllanthus acidus

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Calothrixamides A and B from the Cultured Cyanobacterium Calothrix sp. UIC 10520

The first author of this paper is Camila M. Crnkovic, a Brazilian student who obtained a PhD degree at the School of Pharmacy, University of Illinois, Chicago, under the supervision of Jimmy Orjala.


GEX1A, a Polyketide from Streptomyces chromofuscus, Corrects the Cellular Defects Associated with Niemann-Pick Type C1 in Human Fibroblasts


Peloruside E (22-Norpeloruside A), a Pelorusane Macrolide from the New Zealand Marine Sponge Mycale hentscheli, Retains Microtubule-Stabilizing Properties


Colocynthenins A–D, Ring-A seco-Cucurbitane Triterpenoids from the Fruits of Citrullus colocynthis


Hexaricins, Pradimicin-like Polyketides from a Marine Sediment-Derived Streptosporangium sp. and Their Antioxidant Effects


Investigation of the Biosynthesis of the Lasso Peptide Chaxapeptin Using an E. coli-Based Production System


Diaporindenes A–D: Four Unusual 2,3-Dihydro-1H-indene Analogues with Anti-inflammatory Activities from the Mangrove Endophytic Fungus Diaporthe sp. SYSU-HQ3


Divergent Diels–Alder Reactions in the Biosynthesis and Synthesis of Endiandric-Type Tetracycles: A Computational Study


Target Identification of Yaku’amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase


C–H Hydroxylation in Paralytic Shellfish Toxin Biosynthesis

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Divergent Entry to Gelsedine-Type Alkaloids: Total Syntheses of (−)-Gelsedilam, (−)-Gelsenicine, (−)-Gelsedine, and (−)-Gelsemoxonine


Sodorifen Biosynthesis in the Rhizobacterium Serratia plymuthica Involves Methylation and Cyclization of MEP-Derived Farnesyl Pyrophosphate by a SAM-Dependent C-Methyltransferase


Metabolic and Biosynthetic Diversity in Marine Myxobacteria

Substrate-assisted enzymatic formation of lysinoalanine in duramycin


Biosynthesis and chemical diversity of β-lactone natural products

Graphical abstract: Biosynthesis and chemical diversity of β-lactone natural products

The architectures of iterative type I PKS and FAS

Graphical abstract: The architectures of iterative type I PKS and FAS

Pyridoxal phosphate-dependent reactions in the biosynthesis of natural products

Graphical abstract: Pyridoxal phosphate-dependent reactions in the biosynthesis of natural products

Unusual subunits are directly involved in binding substrates for natural rubber biosynthesis in multiple plant species