• ORGANIC CHEMISTRY OF BIOLOGICAL SYSTEMS

    ROBERTO BERLINCK’S RESEARCH GROUP – INSTITUTO DE QUÍMICA DE SÃO CARLOS, USP

  • ORGANIC CHEMISTRY OF BIOLOGICAL SYSTEMS

    ROBERTO BERLINCK’S RESEARCH GROUP – INSTITUTO DE QUÍMICA DE SÃO CARLOS, USP

  • ORGANIC CHEMISTRY OF BIOLOGICAL SYSTEMS

    ROBERTO BERLINCK’S RESEARCH GROUP – INSTITUTO DE QUÍMICA DE SÃO CARLOS, USP

  • ORGANIC CHEMISTRY OF BIOLOGICAL SYSTEMS

    ROBERTO BERLINCK’S RESEARCH GROUP – INSTITUTO DE QUÍMICA DE SÃO CARLOS, USP

NEWS

Recent Articles – Oct, 12th 2018

From ACS Central Science

Imaging Mass Spectrometry Reveals Crosstalk between the Fallopian Tube and the Ovary that Drives Primary Metastasis of Ovarian Cancer

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This is a great project and a great paper by Laura Sanchez group! A worthwhile reading.

From Chemical Reviews

Production and Synthetic Modifications of Shikimic Acid

From the Journal of Natural Products

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Matrine-Type Alkaloids from the Roots of Sophora flavescens and Their Antiviral Activities against the Hepatitis B Virus

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Spatial Distribution of Collections Yielding Marine Natural Products

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Auranthine, a Benzodiazepinone from Penicillium aurantiogriseum: Refined Structure, Absolute Configuration, and Cytotoxicity

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Irpeksins A–E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity

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From the Journal of the American Chemical Society

Oriented-External Electric Fields Create Absolute Enantioselectivity in Diels–Alder Reactions: Importance of the Molecular Dipole Moment

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This seems to be an incredibly important breakthrough.

From Nature

First report of antimicrobial resistance pre-dates penicillin

This is a very interesting story.

How seventeenth-century sisters broke the mould on scientific illustration

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How to write a thorough peer review

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I highly reccomend the reading of this Nature paper. Well thought.

From Organic Letters

Stereodivergent Total Synthesis of Hapalindoles, Fischerindoles, Hapalonamide H, and Ambiguine H Alkaloids by Developing a Biomimetic, Redox-Neutral, Cascade Prins-Type Cyclization

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Theionbrunonines A and B: Dimeric Vobasine Alkaloids Tethered by a Thioether Bridge from Mostuea brunonis

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Synthesis and Characterization of Anguibactin To Reveal Its Competence To Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii

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Plagiochianins A and B, Two ent-2,3-seco-Aromadendrane Derivatives from the Liverwort Plagiochila duthiana

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From Angewandte Chemie International Edition

Chlorophyll Breakdown in a Fern—Discovery of Phyllobilin Isomers with a Rearranged Carbon Skeleton

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Thinking Outside the Box—Novel Antibacterials To Tackle the Resistance Crisis

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Computational Studies on Biosynthetic Carbocation Rearrangements Leading to Quiannulatene: Initial Conformation Regulates Biosynthetic Route, Stereochemistry, and Skeleton Type

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Total Syntheses of Asperchalasines A–E

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Genome Editing Reveals Novel Thiotemplated Assembly of Polythioamide Antibiotics in Anaerobic Bacteria

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Structure, Total Synthesis, and Biosynthesis of Chloromyxamides: Myxobacterial Tetrapeptides Featuring an Uncommon 6‐Chloromethyl‐5‐methoxypipecolic Acid Building Block

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From the European Journal of Organic Chemistry

Synthesis and biological evaluation of (modified) miuraenamides

From Chemistry World

Chemistry World is the dissemination journal edited by the Royal Society of Chemistry, UK. I consider some Chemistry World articles as of interest to the scientific community.

Wanted: chemistry’s next superstar – The drop in chemistry undergraduates highlights the need for more inspirational scientists

Time to rewrite the textbooks – How science corrects is an important lesson in the classroom

From folklore to pharmacy

Artificial intelligence seeks out new anticancer drugs – A combination of machine learning methods yields promising results for drug discovery

Novartis exit from antibiotics a setback for race against resistance

Derek Barton and shape-shifting molecules

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Recent articles – Oct. 6th, 2018

From the Journal of Natural Products

Bromopyrrole Alkaloid Inhibitors of the Proteasome Isolated from a Dictyonella sp. Marine Sponge Collected at the Amazon River Mouth

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From Nature

Major publishers sue ResearchGate over copyright infringement – Elsevier and the American Chemical Society say that the academic-networking website violates US copyright law.

University tenure decisions still gloss over scientists’ public outreach – Analysis of internal documents shows that promotions and tenure largely depend on metrics such as the number of publications and citations.

Co-production from proposal to paper – Three examples show how public participation in research can be extended at every step of the process to generate useful knowledge.

The best research is produced when researchers and communities work together – Knowledge generated in partnership with the public and policymakers is more likely to be useful to society and should be encouraged.

‘Test-tube’ evolution wins Chemistry Nobel Prize – Frances Arnold, Gregory Winter and George Smith controlled evolution in the lab to produce greener technologies and new medicines.

Better teachers are needed to improve science education – The latest training techniques emphasize classroom practice and design thinking.

Expanding the reach of science – Science education could bring new opportunities to developing countries.

Science and technology education – Science education is being modernized to give students the skills they will need for jobs in the future.

From Organic Letters

Plagiochianins A and B, Two ent-2,3-seco-Aromadendrane Derivatives from the Liverwort Plagiochila duthiana

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One-Pot Total Synthesis of Evodiamine and Its Analogues through a Continuous Biscyclization Reaction

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Total Synthesis of the Proposed Structure of Mycobactin J

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Divergent Coupling of 2-Carbonyl-anilines and Diazo-cyclopentanones: Asymmetric Total Synthesis of (+)-Leucomidine A

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From Organic & Biomolecular Chemistry

First enantioselective total synthesis of altersolanol A

Total synthesis, structural revision and biological evaluation of γ-elemene-type sesquiterpenes

Recent Articles – Sept 30, 2018

From ACS Chemical Biology

Molecular Basis for Autocatalytic Backbone N-Methylation in RiPP Natural Product Biosynthesis

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From Science

Vaccines Against a Vanishing Virus?

From the Journal of Medicinal Chemistry

Two Decades under the Influence of the Rule of Five and the Changing Properties of Approved Oral Drugs

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Structure-Based Drug Design and Identification of H2O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo

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Improved Total Synthesis and Biological Evaluation of Coibamide A Analogues

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From The Journal of Organic Chemistry

A Copper-Mediated Conjugate Addition Approach to Analogues of Aconitine-Type Diterpenoid Alkaloids

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Another remarkable syntheses by Richmond Sarpong’s group

Total Synthesis of (+)-Pyrenolide D

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From the Journal of the American Chemical Society

Twelve-Step Asymmetric Synthesis of (−)-Nodulisporic Acid C

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From Marine Drugs

Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives

A review by Marcel Jaspars and Donatella de Pascalle research teams.

From Nature

Can we engineer ourselves to be lucky scientists?

Brexit is already damaging European science

The quest for postdoctoral independence

No more first authors, no more last authors

From Organic Letters

Tricholumin A, a Highly Transformed Ergosterol Derivative from the Alga-Endophytic Fungus Trichoderma asperellum

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Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva

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Total Synthesis of Anti-tuberculosis Natural Products Ilamycins E1 and F
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From Natural Product Reports

Challenges in the configuration assignment of natural products. A case-selective perspective

From Phytochemistry

Armochaetoglasins A–I: Cytochalasan alkaloids from fermentation broth of Chaetomium globosum TW1-1 by feeding L-tyrosine

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