Recent Articles – Sept 30, 2018

From ACS Chemical Biology

Molecular Basis for Autocatalytic Backbone N-Methylation in RiPP Natural Product Biosynthesis


From Science

Vaccines Against a Vanishing Virus?

From the Journal of Medicinal Chemistry

Two Decades under the Influence of the Rule of Five and the Changing Properties of Approved Oral Drugs


Structure-Based Drug Design and Identification of H2O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo


Improved Total Synthesis and Biological Evaluation of Coibamide A Analogues


From The Journal of Organic Chemistry

A Copper-Mediated Conjugate Addition Approach to Analogues of Aconitine-Type Diterpenoid Alkaloids


Another remarkable syntheses by Richmond Sarpong’s group

Total Synthesis of (+)-Pyrenolide D


From the Journal of the American Chemical Society

Twelve-Step Asymmetric Synthesis of (−)-Nodulisporic Acid C


From Marine Drugs

Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives

A review by Marcel Jaspars and Donatella de Pascalle research teams.

From Nature

Can we engineer ourselves to be lucky scientists?

Brexit is already damaging European science

The quest for postdoctoral independence

No more first authors, no more last authors

From Organic Letters

Tricholumin A, a Highly Transformed Ergosterol Derivative from the Alga-Endophytic Fungus Trichoderma asperellum


Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva


Total Synthesis of Anti-tuberculosis Natural Products Ilamycins E1 and F

From Natural Product Reports

Challenges in the configuration assignment of natural products. A case-selective perspective

From Phytochemistry

Armochaetoglasins A–I: Cytochalasan alkaloids from fermentation broth of Chaetomium globosum TW1-1 by feeding L-tyrosine