New review in NPR – The isolation of water-soluble natural products – challenges, strategies and perspectives

This is a new review article published on line today in RSC Natural Product Reports. It was a considerable volume of work, because it results of one of my main research interests since my PhD in 1992.
During my PhD at the Université Libre de Bruxelles, under the supervision of Professor Jean-Claude Braekman and of Professor Desiré Daloze, I had the opportunity to isolate several new guanidine alkaloids from the Mediterranean sponge Crambe crambe. All compounds I isolated were water-soluble. Since then, I have a long-standing interest in the isolation of bioactive water-soluble natural products. My group have isolated several of such compounds.
This particular review is the first rather comprehensive review on this subject. It was a one-year-and-half effort together with Camila M. Crnkovic, Juliana R. Gubiani, Darlon I. Bernardi, Laura P. Ióca and Jairo I. Quintana-Bulla.
I hope you will enjoy the reading. Please, don’t forget to check out the Supplementary Information for several additional examples of water-soluble natural products belonging to distinct metabolic classes. It also includes a voluminous additional literature examples. Overall, the review has almost 2,000 references.

Read the article here.