NEWS
New group members in 2019
We are pleased to have new researchers in the QOSBIO research group at the Universidade de São Paulo, São Carlos.
Dr. Camila M. Crnkovic joined the group earlier this year. Dr. Camila was awarded with a PhD degree at the University of Illinois, Chicago School of Pharmacy, under the supervision of Professor Jimmy Orjala. Dr. Camila recently presented a seminar entitled “Metabolomics for the Discovery of Natural Products from Cyanobacteria”, based on her PhD thesis, which was truly interesting, showing innovative approaches for the discovery of new cyanobacterial metabolites. Dr. Camila joined the group as a post-doctoral fellow with the very prestigious FAPESP post-doctoral scholarship. Congratulations!
Leandro da S. Oliveira also is a new group member. Leandro graduated in Chemistry at the Universidade Federal de São Carlos. His honors project was developed at QOSBIO, when he decided to apply for the MSc program at the Chemistry Institute of São Carlos, Universidade de São Paulo. He was awarded with a MSc scholarship since did very well in the selection exam at the Chemistry Institute of São Carlos. Congratulations, Leandro!
Other group members are the undergraduate students Giovanna Lima, Lucas Rodrigues, Laura Paulino, Carolina Lucia and Fernando Bermude. Giovanna, Lucas, Laura and Carolina are undergraduate students at the Chemistry Institute of São Carlos, while Fernando is a student of the Physics and Biomolecular Science course at the Physics Institute of São Carlos. We are still waiting for the photos of Carolina and Fernando, though. Lucas has been awarded with a FAPESP undergraduate researcher scholarship – very nice, congratulations Lucas!
Welcome to the QOSBIO group!
Invited review on Endophytic Actinobacteria published in “Progress in the Chemistry of Organic Natural Products”
A very kind invitation by Professor Simon Gibbons to us was to prepare a review for the highly reputed series Progress in the Chemistry of Organic Natural Products. Formerly known as Fortschritte der Chemie organischer Naturstoffe, this series features comprehensive reviews on all aspects of natural products chemistry, biochemistry, technologies, theoretical and practical advances, biosynthesis, particular groups of metabolites, among many other subjects. Professor Gibbons initially invited us to publish a review on marine natural products research in Brazil. However, since the review for the Journal of the Brazilian Chemical Society was already in press, we proposed a review on the subject of Secondary Metabolites of Endophytic Actinomycetes: Isolation, Synthesis, Biosynthesis, and Biological Activities. A short version of the review was initially written by Professor Fernanda Oliveira das Chagas, now at the Universidade Federal do Rio de Janeiro, as the introduction of a post-doctoral proposal. However, Professor Fernanda didn’t have time to submit her proposal: she was hired as assistant professor – very nice! We then agreed to write a more detailed and comprehensive review on that subject, which is currently of interest in our group at São Carlos. PhD student Darlon I. Bernardi and two post-doctoral fellows, Dr. Gabriel Franco and Dr. Afif Monteiro, joined the “review team”. We worked hard, since the submission schedule was tight. Professor Heinz Falk, also editor of the series, contributed with several constructive comments on our review. It was published in April this year, thanks to the team effort and to the Springer very effective publishing production. Read the review here, if a subscription of the series is available at your institution.
Streptomyces endophytes with distinct morphologies. Very beautiful picture from the article by Anne van der Meij, Joost Willemse, Martinus A. Schneijderberg, René Geurts, Jos M. Raaijmakers and Gilles P. van Wezel, “Inter- and intracellular colonization of Arabidopsis roots by endophytic actinobacteria and the impact of plant hormones on their antimicrobial activity”, doi: https://doi.org/10.1101/222844.
New bromopyrrole alkaloids from a Dictyonella sp. sponge
The recent investigation of new bromopyrrole alkaloids by a former MSc. student, Renata Torres, resulted in the discovery of 4-debromooroidin (1), 4-debromougibohlin (2), 5-debromougibohlin (3) and 5-bromopalau’amine (4) from the MeOH extract of the sponge Dictyonella sp. These new alkaloids were isolated along with the known hymenidin (5) and (+)-monobromoisophakellin (6). Curiously, the bromination pattern of compounds 1–4 is rather unusual for the marine sponge brominated pyrrole alkaloids. Usually, bromination at C-3 is more frequently observed for these compounds. The alkaloids were tested as proteasome inhibitors by the group of Dr. Daniela Trivella, researcher at the LNBio Laboratory at CNPEM. Results showed that 5-bromopalau’amine (4) was the most active alkaloid, in agreement with previous results observed for these metabolites when tested as proteasome inhibitors. Samples of the sponge were made available by a group of researchers of the Rio de Janeiro Botanical Garden and Federal University of Rio de Janeiro, who collected the animal during an expedition at the mouth of the Amazon river. Spectroscopic data collection and analyses were performed collaboratively with Prof. Antonio G. Ferreira at the Federal University of São Carlos and with Dr. David E. Williams and Prof. Raymond J. Andersen at the University of British Columbia. This investigation was published in the Journal of Natural Products, and corresponds to the MSc dissertation project of Renata Torres.
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