• ORGANIC CHEMISTRY OF BIOLOGICAL SYSTEMS

    ROBERTO BERLINCK’S RESEARCH GROUP – INSTITUTO DE QUÍMICA DE SÃO CARLOS, USP

  • ORGANIC CHEMISTRY OF BIOLOGICAL SYSTEMS

    ROBERTO BERLINCK’S RESEARCH GROUP – INSTITUTO DE QUÍMICA DE SÃO CARLOS, USP

  • ORGANIC CHEMISTRY OF BIOLOGICAL SYSTEMS

    ROBERTO BERLINCK’S RESEARCH GROUP – INSTITUTO DE QUÍMICA DE SÃO CARLOS, USP

  • ORGANIC CHEMISTRY OF BIOLOGICAL SYSTEMS

    ROBERTO BERLINCK’S RESEARCH GROUP – INSTITUTO DE QUÍMICA DE SÃO CARLOS, USP

NEWS

News from the Brazilian Media – Dec 13th, 2018 – in Portuguese

Correios lançam selos especiais em homenagem a cientistas brasileiros em São Paulo

Ecossistema subterrâneo com bilhões de microorganismos é encontrado por cientistas

MEC deve apresentar ‘base curricular de professores’ nos próximos dias

Recent articles – Dec 9th, 2018

From the Journal of the American Chemical Society

Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids

Enantioselective Synthesis of des-Epoxy-Amphidinolide N

Enantioselective Conversion of Oligoprenol Derivatives to Macrocycles in the Germacrene, Cembrene, and 18-Membered Cyclic Sesterterpene Series

Discovery and Characterization of 1-Aminocyclopropane-1-carboxylic Acid Synthase of Bacterial Origin

Adaptation of a Bacterial Multidrug Resistance System Revealed by the Structure and Function of AlbA

Total Synthesis of (−)-Mitrephorone A

Synthesis of Myrocin G, the Putative Active Form of the Myrocin Antitumor Antibiotics

Gramillin A and B: Cyclic Lipopeptides Identified as the Nonribosomal Biosynthetic Products of Fusarium graminearum

Progress Toward a Semi-Synthetic Organism with an Unrestricted Expanded Genetic Alphabet

This is an amazing paper.

From Nature

A chemical defence against phage infection

Do luxe labs shape science?

Does science have a bullying problem?

Ban bullying in science

How science supports São Paulo

Stop exploitation of foreign postdocs in the United States

Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity

From Organic Letters

A Phenylpyruvic Acid Reductase Is Required for Biosynthesis of Tropane Alkaloids

Aspersecosteroids A and B, Two 11(9 → 10)-abeo-5,10-Secosteroids with a Dioxatetraheterocyclic Ring System from Aspergillus flocculosus 16D-1

Curtachalasins A and B, Two Cytochalasans with a Tetracyclic Skeleton from the Endophytic Fungus Xylaria curta E10

Antroalbocin A, an Antibacterial Sesquiterpenoid from Higher Fungus Antrodiella albocinnamomea

Genome Mining for Mycemycin: Discovery and Elucidation of Related Methylation and Chlorination Biosynthetic Chemistries

Seongsanamides A–D: Antiallergic Bicyclic Peptides from Bacillus safensis KCTC 12796BP

Vlasoulamine A, a Neuroprotective [3.2.2]Cyclazine Sesquiterpene Lactone Dimer from the Roots of Vladimiria souliei

Elucidation and Heterologous Reconstitution of Chrodrimanin B Biosynthesis

From Phytochemistry

Mulberry Diels-Alder-type adducts from Morus alba as multi-targeted agents for Alzheimer’s disease

Fusaricates H-K and fusolanones A-B from a mangrove endophytic fungus Fusarium solani HDN15-410

Recent articles – Dec 7th, 2018

From the Journal of Natural Products

Onydecalins, Fungal Polyketides with Anti-Histoplasma and Anti-TRP Activity

Isolation and Characterization of Anaephenes A–C, Alkylphenols from a Filamentous Cyanobacterium (Hormoscilla sp., Oscillatoriales)

Isotopic Labeling Studies Reveal the Patulin Detoxification Pathway by the Biocontrol Yeast Rhodotorula kratochvilovae LS11

Lentiquinones A, B, and C, Phytotoxic Anthraquinone Derivatives Isolated from Ascochyta lentis, a Pathogen of Lentil

Macrocyclic Trichothecene Mycotoxins from a Deadly Poisonous Mushroom, Podostroma cornu-damae

These findings are really interesting. Trichothecene polyketides are common metabolites produced by filamentous fungi. This mushroom appears to be the first basidiomycete for which isolation of trichothecenes have been reported. Are these truly mushroom metabolites, or maybe produced by a symbiotic fungus?

Elucidation of Relative and Absolute Configurations of Highly Rearranged Diterpenoids and Evidence for a Putative Biosynthetic Intermediate from the Australian Nudibranch Goniobranchus geometricus

From The Journal of Organic Chemistry

Vinyl-1,2,4-oxadiazoles Behave as Nucleophilic Partners in Morita–Baylis–Hillman Reactions

This is a paper from Professor Fernando Coelho’s group at the State University of Campinas, São Paulo, Brazil.

Porphyrins as Photoredox Catalysts in Csp2–H Arylations: Batch and Continuous Flow Approaches

This is a paper from Professor Kleber de Oliveira’s group at the Federal University of Sao Carlos, São Paulo, Brazil.

Asymmetric Total Synthesis and Evaluation of Antitumor Activity of Ophiorrhisine A and Its Derivatives

Total Synthesis of the Ortho-Hydroxylated Protoberberines (S)-Govaniadine, (S)-Caseamine, and (S)-Clarkeanidine via a Solvent-Directed Pictet–Spengler Reaction

Total Synthesis and Absolute Stereochemical Assignment of Microgrewiapine A and Its Stereoisomers

Enantioselective Total Synthesis of (+)-Nocardioazine B

Total Synthesis of (−)-Mucosin and Revision of Structure

From Nature Chemical Biology

Expanding the terpenoid kingdom

Identification of Chaoborus kairomone chemicals that induce defences in Daphnia

From Nature Chemistry

2018 NOBEL PRIZE IN CHEMISTRY – Exploiting evolution

From Chemical Society Reviews

Recent applications of C–H functionalization in complex natural product synthesis

From Natural Product Reports

Non-volatile natural products in plant glandular trichomes: chemistry, biological activities and biosynthesis

Nonribosomal antibacterial peptides that target multidrug-resistant bacteria

Science and Science Podcasts

The universe’s star formation history and a powerful new helper for evolution

The worst year ever and the effects of fasting

A systems biology approach to unravelling the complexities of immune system development and function

From the University of São Paulo newspaper (Jornal da USP)

Platform grants access to USP’s intellectual production since 1985

From Bioorganic & Medicinal Chemistry Letters

Tetradehydrohalicyclamine B, a new proteasome inhibitor from the marine sponge Acanthostrongylophora ingens

From Phytochemistry

Transport of organic substances through the cytoplasmic membrane of cyanobacteria