New review on natural guanidines

A new review published in Natural Product Reports discuss the chemistry and biology of guanidines isolated from microorganisms, animals and plants. It was a team effort with Darlon I. Bernardi, a PhD student in my group, Professors Taicia Fill and Igor Jurberg both at the Instituto de Química of UNICAMP, and Alessandra A. G. Fernandes, a PhD student at Professor Igor’s group. Excluding the three years literature survey, which had to be systematically done, the manuscript preparation took 3,5 months. Needless to say that working in the review was simultaneous to the COVID-19 pandemic start in Brazil, a situation that considerably affected the academic activities in the Brazilian universities. Nevertheless, our team was very focused and did work very hard to organize and prepare the manuscript, which corresponds that second largest survey on natural guanidines in this review series. The largest one was the first review, published in 1995 in Progress in the Chemistry of Organic Natural Compounds.

The 2017-2019 literature analysis showed a change in the research of guanidines natural products. Currently there is a considerable effort to better understand the biosynthesis and ecological roles of natural guanidines, instead of biodiscovery. Several aspects of guanidine secondary metabolites chemistry and biology are discussed in detail in our review, which can be read here.